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These immune-beneficial effects likely arise from a pre-activation of the immune cells by the UPR mt stress response

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FAs in the liver originate from the diet (1530% of the liver FA pool), de novo lipogenesis (up to 30% of liver FA pools during feeding) and recycling of FAs released from adipose tissue during fasting 10

doi: 10.2174/1570159X21666230222092029 143 MagnusP.BirkeC.VejrupK.HauganA.AlsakerE.DaltveitA

We were interested in evaluating for possible adverse effects of MT-II including anxiety-like and repetitive behavior, in particular over a subacute period on the order days as opposed to acute treatment on the order of hours as in previous reports [45]