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VPAC1 KO mice show growth retardation, intestinal obstruction, and hypoglycemia 48 , suggesting that VPAC1 is also involved in glucagon secretion, which counteracts the hypoglycemic effects of insulin

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Nat Neurosci 17(1):1723
Dysregulation of this axis underpins a wide array of pathologies, from myocardial infarction and heart failure to stroke, hypertension, and neurodegenerative disorders, driven by mechanisms such as sympathetic overactivation, inflammatory cascades, and hormonal imbalances
The samples were then processed for metabolomic analysis, which was conducted by Allwegene Technology Co., Ltd (Beijing, China)
