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In myeloid derived suppressor cells (MDSCs), serine/threonine kinase PIM1-mediated phosphorylation of STAT3 at the S727 site enhances STAT3 transcriptional activity and leads to increased PPAR expression, which in turn enhances FAO expression and promotes melanoma cell resistance to PD-L1 treatment [164]

Kyn, 3OHK and 3OHKG are found prominently in young lenses (102), but decline at a rate of ~12% per decade, with kyn and 3OHK being nearly undetectable in 80 year old lenses (110)

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doi: 10.1016/j.colsurfb.2017.10.005