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In summary, SLC7A11 overexpression inhibits ferroptosis in cancer cells by synthesizing cysteine and GSH from cystine uptake and indirectly reducing lipid ROS stress by activating GPX4 to reduce lipid hydroperoxides

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Clinical trial protocols are designed with specific criteria to ensure the inclusion of eligible participants and exclude those who may be at higher risk

30 A reduced risk of pancreatic cancer was reported by Fu and Zeng 31 from their meta-analysis study involving 5,654 cases and 1,009,374 individuals

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