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Description
TGF-, through the IKK-NF-B pathway, triggers a transformation in epithelial cells, prompting them to express functional mesenchymal characteristics that includes the upregulation of -SMA to support cell division, the induction of intermediate filament vimentin for increased cellular motility, and the promotion of ECM formation and deposition through the expression of collagen type 1A, fibronectin 1, and MMP9 (113)

General information

Nature 466 , 779782 (2010)
doi: 10.1186/1742-2094-8-105
Belsky, D
