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Nevertheless, these KO mice fail to respond to mechanical loading in promoting periosteal and endosteal bone formation, and the expression of early mechanoresponsive genes (IGF-I, Cox-2, c-fos), osteogenic markers (RUNX2, and osteocalcin) and canonical Wnt signaling genes (Wnt10b, Lrp5, Dkk1, sFrp2)

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PROVEAN yielded very poor correlations of = 0.44 ( p = 0.27), 0.59 ( p = 0.09), and 0.64 ( p = 0.05) for age of onset, disease severity, and clinical vitamin B 6 response, respectively

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