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NAFLD is estimated to progress to a more severe condition called nonalcoholic steatohepatitis (NASH) in about one-third of NAFLD patients, as well as to increase the risk of cirrhosis and liver cancer (13)

The main function of carnitine in the body is to facilitate the transport of long-chain fatty acids into the mitochondria, the energy powerhouses of cells

Subsequent animal experiments further confirmed that SCFAs, particularly butyrate, contributes to peripheral androgen synthesis, thereby promoting ADT resistance in PCa (71)

3 When there is reduced elimination, or production is increased, ammonia accumulates and is shunted to the systemic circulation resulting in brain accumulation and subsequent dysfunction