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One of the possible mechanisms responsible for the pathophysiology could be associated with a deficiency in mitochondrial transport or mitophagy since it could increase the accumulation of dysfunctional mitochondria in the axon of motor neurons (Menzies et al., 2002)

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doi: 10.1016/j.niox.2013.10.011

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A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches