loss os glutathione redox homeostatiss of homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation Frontiers | Glutathione: new roles

They are water-soluble and function in the cytoplasm and mitochondria [47,76-79]

doi:10.1002/lio2.35 Talaat HS, Abuhadied G, Talaat AS, Abdelaal MS

Cysteine-glycine, a breakdown product of extracellular glutathione (Figure 1E), was also elevated in kidneys with TLS, suggesting extracellular glutathione transport

The varied expression of influx/efflux transporters (e.g., ABCB1/P-gp) [44], divergent pro-survival signaling, apoptosis pathways or DNA repair capacity [45], as well as the expression profile of non-coding RNAs [46] and epigenetic regulatory factors [47] may cause the different IC50 values of APS

Wang L, Lu K, Lou X, Zhang S, Song W, Li R, Geng L, Cheng B