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The loss of motor and sensory function, along with chronic pain caused by sciatic nerve injury, significantly impacts patients quality of life

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If the activity of methylmalonyl-CoA mutase is absent or decreased, e.g., due to hereditary defects of the apoprotein or to B 12 deficiency, toxic methylmalonic acid (MMA) is formed and the excess of methylmalonic acid is excreted in the urine

C-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-met