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However, the absence of human clinical trials means the relevance and safety of these mechanisms in humans remains unestablished

Clinical trials confirmed no negative effects on carbohydrate metabolism

However, recent publications seem to quench the translation of these findings in humans, proving that the in vivo TG-lowering effects of DGAT2 inhibitors observed in murine models are not present in a primate model (14)

Soulage CO

Banks W.A., Kastin A.J., Coy D.H
