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Nutrients 8 , 776 (2016)

Intestinal movement improved Rehydrates/softens your stools and stimulates gut muscles to ease evacuation for predictable relief vs natural remedies (fruits, tea, water)

Additionally, even at low doses, these medication minimizes dopamine release among experimental animals

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PLoS One 8:e61271 Kim HG, Yoo SR, Park HJ, Son CG (2013) Indirect moxibustion (CV4 and CV8) ameliorates chronic fatigue: a randomized, double-blind, controlled study
