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Description
Ferroptosis in osteoarthritis: towards novel therapeutic strategy
10.1016/j.neuro.2005.07.003 48 EvansG
Lipoxygenases and phosphorylase kinase G2 are two key drivers of lipid peroxidation (Yang et al., 2016), which can directly damage phospholipids and intrigue ferroptosis
Specifically, MSU directly initiates macrophage protein hydrolysis mediated by caspase-1, which processes the NLRP3 inflammasome and heightens the secretion of IL-1 and IL-18 (35)
The evaluation doesnt consist only of assessing the procedure site, confirming the indication, or obtaining consent
