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Compounded drugs pose a higher risk to patients than FDA-approved drugs because compounded drugs do not undergo FDA premarket review for safety, quality or effectiveness

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For example, fructans can be very supportive of probiotic lactic acid bacteria and stimulate their growth (69), and glucose derived oligosaccharides like polydextrose can increase intestinal Ruminococcus intestinalis and enhance butyrate production (70)

Clinical trials used doses as high as 1 mg per day without safety concerns, but 300 mcg is the most commonly referenced dose in peptide medicine literature and in the investigational protocols that have been published since the formal trials concluded