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1 Amantadine may be used as monotherapy for up to 12 months before the initiation of L-dopa to target mild symptoms including tremor and to reduce L-dopainduced dyskinesias in later disease

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Werner syndrome (WS), which is distinguished by severe metabolic dysfunction, dyslipidemia, early atherosclerosis, and insulin resistance diabetes, is thought to most closely mimic normal aging

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A study found that 8 out of 10 patients with NF1 who only had CaLS at the first visit and who on physical examination had JXGs or NA, subsequently developed the disease,4 and another study found that NF1 was subsequently confirmed in children with JXGs and CaLS.7 Therefore, considering that JXG is the most frequent tumor in NF1, it is probable that the coexistence of CaLS and JXGs in small children should not be considered a casual finding but rather one highly indicative of the disease