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10.1016/j.bpj.2008.10.004

Pathological changes such as herniated intervertebral disc, inflammatory factor infiltration, and nerve ingrowth are closely related to pain (Stefanakis et al., 2012

Bile acids also promote colonic water secretion, through TGR5-mediated activation of adenylate cyclase, which stimulates chloride secretion through the cystic fibrosis transmembrane conductance regulator (CFTR) (174)

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