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Description
This dual action has been demonstrated consistently in obese rodent models

Reported biochemical potency against human NNMT is in the low-micromolar range with cellular EC values in the low-micromolar range for suppression of 1-MNA and lipogenesis, with selectivity over related methyltransferases and NAD-salvage enzymes [1,6,7]

Fidaleo, M

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Inadequate initial treatment may result in suboptimal responses and persistent symptoms
