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In a post hoc analysis after 13 years of the study, a 13% increased risk of vitamin B12 deficiency per year of metformin use was reported (Aroda et al, 2016)
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Experimental Results: Bone mineral density (BMD): OVX control group: Lumbar BMD decreased by 28% and hip BMD decreased by 25% compared to Sham group (successful osteoporosis model)
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however, comprehensive, long-term, peer-reviewed data for this trial remains conspicuously absent from the scientific literature, leading researchers to treat such claims with extreme skepticism
