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102 In vitro treatment with 1-h H 2 O 2 demonstrated that the catalytic activity of POLG was reduced to 50% of the original level with significantly lower DNA binding efficiency
(2025) 99:e0068525
Mechanisms involving SAMe have been described, such as DNA and histone methylation, MAT enzymes regulation and polyamines synthesis
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High intracellular GSH is associated with drug resistance by promoting drug conjugation and transport-mediated efflux
