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The blockade of proinflammatory cytokine receptors results in restored GABA function and the attenuation of mechanical and cold hypersensitivity [176]

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Resident CNS immune cells, such as microglia and astrocytes, detect danger-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and Nod-like receptors (NLRs) ( In AD, the presence of abnormally phosphorylated tau protein and extracellular deposits of A peptide are key pathological features ( The NLRP3 inflammasome is a critical player in neuroinflammation, activated by DAMPs and PAMPs in microglia, astrocytes, and neurons ( in vitro systems or animal models

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