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DHEA plays a role in maintaining ovarian immune homeostasis by modulating the balance between Th1 and Th2 immune responses within the ovary through NF-B regulation, which decreases IL-2 and IL-10 (80)

10.1038/nri3041 113 GlodzikL.RandallC.RusinekH.de LeonM

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These effects were mediated primarily through activation of the PI3K/AKT pathway, which subsequently upregulated mTOR and RhoA/p-MLC