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By comparing the wild-type (wt) and three pathogenic mutations (R248W, R248Q, R249S) in the noncore regions, we reveal that flanking alterations remodel -sheet aggregates and induce conformational plasticity in -strand ensembles through the generation of novel conformational substates and selective elimination of existing conformational substates

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Delta-wave sleep, also known as slow-wave sleep, is essential for physical and mental recovery, making DSIPs influence on this stage particularly noteworthy