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Anti-Aging and Skin Regeneration: In dermatological applications, AHK-Cu promotes the synthesis of collagen, elastin, and glycosaminoglycans, which are vital for improving skin firmness and reducing the appearance of wrinkles

In vivo , Sirt1 protein expression was also significantly decreased in the livers of mice by NNMT knockdown [14]

doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois

Importantly, lean mice on regular diets did not show significant weight loss at the same doses

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