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You might have just had a shudder, and a flashback to first year biochemistry, but youll recall that ACoA is a really common and important co-factor in a whole heap of biochemical processes concerning energy generation, most notably the Krebs cycle

In some cases, a single molecule from the bloodstream can be detected

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McGraw Hill Dong BJ & Greenspan FS (2015): Thyroid & Antithyroid Drugs (Chapter 38)