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Consistently, NAD + deficiency leads to an impaired DDR and an increased genomic instability, suggesting an interplay between genomic stability and NAD + metabolism

Scratch-wound assays mainly evaluate two-dimensional closure across a culture surface and are sensitive to wound width, cell confluence, proliferation rate, matrix coating, and serum concentration

[DOI] [PMC free article] [PubMed] [Google Scholar] 189.Saccoccia F., Di Micco P., Boumis G., Brunori M., Koutris I., Miele A.E., Morea V., Sriratana P., Williams D.L., Bellelli A., et al

[0549] In certain embodiments the expression vector may be provided to a cell in the form of a viral vector