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Besides, in humans, methylation of the 5-HT receptor 2A gene (HTR2A) promoter, has been associated con with psychiatric conditions such as schizophrenia and bipolar disorder effects in four analyzed cytosines in the promoter region, located 166 (L1), - 1439 (L2), -1421 (L3) and 1224 (L4), particularly some specific genetic polymorphisms (rs6311 and rs6306)