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ET as an Antioxidant The fact that mammals do not synthesize ET, but import it via a specific evolutionarily conserved transporter, and retain it with high avidity suggests important physiological functions

This is indicative of in situ oxidative stress and/or generation of APAPs reactive intermediate and a disruption in brain redox balance sufficient enough to be detected by this oxidative stress sensor (Figure 4)(127)

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10.3390/antiox7070089 10.3390/antiox7070089 [DOI] [PMC free article] [PubMed] [Google Scholar] Nechifor MT, Neagu TM, Manda G (2009) Reactive oxygen species, cancer and anti-cancer therapies