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During catalysis, electrons from NADPH are transferred to FAD and subsequently relayed through a Cys59-Cys64 disulfide bridge to the Sec residue within the C-terminal domain

This is an imbalance between harmful molecules called free radicals (or reactive oxygen species) and the antioxidants that neutralize them

Bertoni-Freddari C, Fattoretti P, Caselli U, Paoloni R

Importantly, were observed mainly as exacerbations rather than incident asthma diagnosis, showing that PM 2.5 may act to amplify disease activity in genetically predisposed individuals rather than to initiate asthma de novo

For number and definition of replicates for experimental approaches, please see the corresponding Methods sections