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Central Integration: The nucleus tractus solitarius (NTS) serves as the primary integration center, participating in emotional encoding via the parabrachialamygdala pathway while regulating sleep-wake cycles through ascending reticular formation projections (38)

Subsequent vasoconstriction and inflammation ensue, leading to vessel wall remodeling and, finally, to the formation of atherosclerotic lesions as the hallmark of advanced disease

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Conversely, CTT1 expression exhibited a different profile: it was rapidly activated by H 2 O 2 in the early exponential phase, but it was repressed in the early stationary phase, showing an earlier decrease in gene expression in the absence of MEL

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