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As expected, M1 high tumors demonstrated significantly higher favorable immune activity, such as, Lymphocyte Infiltration Signature Score, TIL Regional Fraction Score and IFN-gamma Response in TCGA cohort (Fig

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We also discuss how metabolic surgeries, such as Roux-en-Y gastric bypass and sleeve gastrectomy, can double peak blood alcohol concentrations due to faster absorption and reduced first-pass metabolism, significantly increasing the risk of alcohol use disorder and alcohol-related harm an effect that warrants increased monitoring of alcohol use post-surgery, particularly in pediatric patients