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In addition, MOTS-c treatment significantly increased the phosphorylation level of AMPK and inhibited the activation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), P38, and c-Fos expression induced by formalin (8)
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Gastrointestinal conditions such as pernicious anemia (autoimmune destruction of gastric parietal cells), Crohn's disease, celiac disease, and prior gastric or ileal surgery significantly impair absorption
In mice, treated females generated oocytes with improved spindle integrity and reduced DNA fragmentation
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