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It is also produced in the body from L-citrulline, another semi-essential amino acid produced in the gastrointestinal tract from glutamine, which is converted into L-arginine in the kidneys
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The first two raise both serotonin and norepinephrine, and it is the impact on norepinephrine that is activating
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10.1016/j.jep.2021.114207 102 LiY.ZhangL.RenP.YangY.LiS.QinX.et al (2021d)
