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Rahbar et al., 2005[40]

Branched-chain amino acids in cardiovascular disease

Due to hyperinflation and long-term unfavourable mechanical position, the diaphragm is forced to remain in a state of contraction, which is easy to cause the decline of diaphragm compliance and contraction force, leading to diaphragm fatigue (Figure 1)

Trumbeckaite S, Opalka JR, Neuhof C, Zierz S, Gellerich FN: Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function

Recent studies suggest that statins may cause myopathy by depleting isoprenoids and interfering with intracellular calcium signaling