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In human HT-1080 fibrosarcoma cells, treatment of erastin (Era) restricts the production of glutathione ( Supplementary Figure S13 ), and therefore inactivates GPX4 and triggers ferroptosis ( 102 prevented erastin-induced ferroptosis evidently in a dose-dependent manner ( Figure 8A ), even when the concentration of erastin reached to 100 M ( Figure 8B )

Neuroinflammation is initiated primarily by the activation of microglia, the resident immune cells of the central nervous system (Fornari Laurindo et al

Indeed, terminally differentiated neurons rely on efficient quality control systems such as the autophagic-lysosomal pathway for maintaining their delicate proteostasis, which is gradually impaired as the brain ages (Figure 1A)

Trace Elements as Immunoregulators in SARS-CoV-2 and Other Viral Infections