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In the gut, T cells maintain immune balance, differentiating into proinflammatory (Th1, Th17) or anti-inflammatory [Th2, regulatory T cells (Tregs)] subsets ( 2.1.3 The link between gut microbiome and AD AD, based on emerging research over the past two decades, may be associated with chronic stress, where prolonged exposure to adverse life events (such as MDD and anxiety) increases the risk of developing the disease (Huang et al., 2024)

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The findings indicated that metformin treatment led to enhanced endometrial tolerance through the downregulation of tolerance-related miRNAs, specifically miR-1910-3p and miR-491-3p, resulting in elevated expression of endometrial tolerance markers HOXA10 and ITGB3 in patients with PCOS