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Oxidative damage due to doxorubicin-induced free radical results in decreased GSH and depletes superoxide dysmutase in cardiac muscle.[9496] These molecules alter DNA, causing mitochondrial dysfunction, eliciting a cellular calcium overload, causing acute depression of GSH levels and inducing the release of catecholamine.[97,98] The incidence of cardiac toxicity can be reduced by using a weekly schedule of doxorubicin rather than every 21 days (lower peak drug levels), or by the use of dexrazoxane, a derivative of EDTA.[98] This agent may enhance mucositis and myelosuppression during treatment, and also has been reported in one study to alter antitumor efficacy.[99] Mechanisms by which glutamine plays a protective role in the myocardial cell is through upregulation of GSH and, secondly, induction of heat shock protein (HSP)
Enhancement by BPC 157 of granulation tissue formation and collagen deposition

[DOI] [PubMed] [Google Scholar] 110.Sinha SR, Haileselassie Y, Nguyen LP, Tropini C, Wang M, Becker LS, et al

doi:10.1093/cid/ciu065 Dinleyici EC, Eren M, Dogan N, Reyhanioglu S, Yargic ZA, Vandenplas Y