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(93 subjects, 12 weeks) : A double-blind, placebo-controlled, split-face study showed that pal-KTTKS provided significant improvement versus placebo for wrinkle and fine line reduction by both quantitative technical measurement and expert grader analysis

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Increased VEGFR2 expression or activation suggests enhanced responsiveness of endothelial cells to VEGF-family ligands

Additional Potential Benefits Beyond sleep and stress, DSIP may provide other systemic advantages: Pain management: Preliminary studies suggest DSIP could influence pain pathways, potentially lowering pain perception

[DOI] [PMC free article] [PubMed] [Google Scholar] Gronfier C, Chapotot F, Weibel L, Jouny C, Piquard F, Brandenberger G