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Sulforaphane activates the cerebral vascular Nrf2ARE pathway and suppresses inflammation to attenuate cerebral vasospasm in rat with subarachnoid hemorrhage

Moreover, there is a suggestion that an age-related decrease in cellular energy may predispose neurons to disruptions in Ca2 + homeostasis, and subtherapeutic doses of lithium could attenuate these disturbances, offering a potential therapeutic strategy to modify disease progression in AD [114]

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To avoid metHb accumulation, reducing pathways mediated by cytochrome b5 or flavin coupled with NADH- or NADPH-dependent metHb reductases (MHbR), respectively, keep the level of metHb in erythrocytes at less than 1% of the total Hb under normal conditions (48)

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