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The selection was guided by reported structureactivity relationship (SAR) data and the known pharmacological relevance of these scaffolds in modulating PDE10A and other neurologically relevant targets

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Interleukin-6 plays a protective role in development of cisplatin-induced acute renal failure through upregulation of anti-oxidative stress factors

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229,230 In a model of barrier dysfunction induced by intestinal ischemiareperfusion injury, the expression of microRNA-21 (miR-21-5p and miR-21-3p) was increased, while that of TJ proteins, including occludin and CLDN1, was decreased