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Since astrocytes require Phgdh to synthesize L-serine from glucose, astrocyte de novo synthesis of L-serine may be a previously unrecognized regulatory mechanism for the NMDA receptors co-agonism by D-serine (Masuoka et al., 2019


2021;80 doi: 10.1016/j.cellsig.2020.109905

The elegance of the single-molecule design is that all three effects rise and fall together on one predictable once-weekly curve, instead of three separate drugs each with its own half-life and interaction profile

doi: 10.1089/ten.2004.10.1617
