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They function as messengers that instruct cells to: Repair damaged tissue Produce growth factors Improve mitochondrial function Reduce inflammation Enhance immune regulation Support collagen production Improve cellular communication Promote regeneration As we age, natural peptide production declines significantly, contributing to many age-related changes

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In wild-type mice, all four Rspondins , known to play an important role in augmenting Wnt signaling 34 , progressively decrease during mid-to-late anagen, while the antagonists Notum and Dkk2 gradually accumulate