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These products [dopamine quinones, 6-hydroxydopamine and reactive oxygen species (ROS) such as O 2- ] can be particularly harmful to cells by reacting nonspecifically, causing irreversible cell damage and apoptosis

Building on this discovery, we develop RC-1 as a reversible covalent BTK PROTAC with a high target occupancy as its corresponding kinase inhibitor

205 ACSL1 promotes peritoneal metastasis of ovarian cancer cells by reducing lipid peroxidation by lipid reprogramming

Nevertheless, it has been hypothesized that environmental exposures are able to modify the epigenetic control on gene expression, and that the phenotype is the result of the interaction between genotype and environment

This makes it distinct from compounds that act primarily through stimulation or neurotransmitter release