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Complementing this, a prospective cohort of 252 T2DM patients showed significantly higher serum C3 and C5 levels in NPDR compared with non-DR groups, and a multifactorial analysis confirmed C3 activation as an independent predictor of DR development and progression (48)
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Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, Adser H, Jakobsen AH, Pilegaard H, Nielsen HB, Secher NH (2010) Endurance training enhances BDNF release from the human brain
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