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10.1113/jphysiol.2006.106898

However, the presence of biological barriers in tumors, such as low oxygen concentration, high interstitial fluid pressure and poor tumor penetration, makes it difficult for liposomes to achieve precise targeted delivery to tumor sites

Expanded options for pathway profiling are in the graphic below: Functionality biomarkers Cytochrome P450 enzyme activity Albumin production Urea production Clinical liver health biomarkers Lactose dehydrogenase (LDH) release Adenosine Triphosphate (ATP) Aspartate Transferase (AST)/Alanine amino transferase (ALT) Optional profiling analysis Quantitative PCR Transcriptomics Oxidative stress Mitochondrial dysfunction Steatosis Bile acid synthesis/ transport dysregulation Inflammatory response (Human DILI assay only) Proven predictability, reliability and robustness Using a panel of IQ MPS Consortium-recommended reference compounds, the PhysioMimix DILI assay delivered 100% sensitivity, 85% accuracy and 100% precision, outperforming other in vitro approaches

doi: 10.1007/s10600-016-1730-4 35

Vitals: a quick safety check of blood pressure and heart rate