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The case of NAC encapsulates the core challenges of MIRI therapy: while its mechanism of enhancing endogenous defenses is conceptually superior to direct scavenging (as argued in Section 2.3), its clinical potential is ultimately nullified by the formidable practical hurdles of delivery and timing required to counteract the rapid and localized oxidative burst (Section 2.1)

If the reconstituted solution will not be used immediately, check whether the drugs instructions allow storage

As noted above, the incorporation of modified nucleosides like pseudouridine and 5-methylcytidine in place of uridine can mask the mRNA from TLRs and RIG-I, dramatically lowering interferon activation [2]

Mishra et al., 2021)

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