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CysteineGSH axis in fibrosis control GSH, a key intracellular antioxidant, is synthesized from glutamate, cysteine, and glycine, with glutamatecysteine ligase (GCL) catalyzing the rate-limiting step[119]

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With the accumulation of senescent cells, radiationinduced oxidative stress and activation of PKC are also able to increase the expression of p16, which further enhances the process of cellular senescence