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2024 Jan;48(1):55-64

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Methods Mol Biol 2006

CPT-1B is the muscle isoform and is highly expressed in heart, skeletal muscle and testis [2]

It can pass easily to the brain and is both water and fat-soluble Liu and colleagues tested aged rats with oral acetyl-L-carnitine and lipoic acid to see if the supplementation reduced mitochondrial aging in the brain [1] A group from Oregon State University reviewed the literature and suggested that together, acetyl-L-carnitine and lipoic acid were able to protect the heart from aging as well as reverse age-related changes [2]