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Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) recognizes peptidoglycans from the bacterial wall and suppresses commensal bacteria extension, such as Enterobacteriaceae, Clostridiales, and Bacteroides spp

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The PTPN22 (R620W) risk variant encodes a hyperactive phosphatase that hypersuppresses T-cell receptor signaling and paradoxically impairs thymic negative selection and allows escape of autoreactive T cells [60, 73]

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