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However, a direct comparison of these results was not possible due to a lack of congruence between the (a) age groups investigated, namely, clear-cut young and old groups (MRS (Emir et al., 2011, Hupfeld et al., 2021)) versus young + middle-aged and old groups (biochemical assay (Tong et al., 2016)), and/or (b) specific ROIs used: medial frontal (Hupfeld et al., 2021) versus prefrontal dorsolateral cortex (Tong et al., 2016), and occipital cortex (Emir et al., 2011) versus primary visual cortex (Tong et al., 2016)
0.1, 1, and 10 g/mL) promote endothelial senescence in porcine coronary arteries via increased -galactosidase activity, ROS accumulation, and elevated expression of senescence-associated proteins p53, p21, and p16 [128]

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Table 4 )

(yes, different syringe) He tested very low B12 before supplementing (though barely in range) and is having some cognitive decline, so this works for us
