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The calculations are based on age, gender, cholesterol levels, systolic blood pressure, body mass index (BMI), estimated glomerular filtration rate (eGFR), smoker versus non-smoker status, and current use of blood glucose-lowering, blood pressure-lowering, and cholesterol-lowering drugs

discussion S47S-38 Butterfield D, Castegna A, Pocernich C, Drake J, Scapagnini G, Calabrese V (2002) Nutritional approaches to combat oxidative stress in Alzheimers disease

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Depending on the severity of symptoms, a person may need to call 911 if theyve taken large amounts of melatonin and are experiencing chest pain, extremely high blood pressure, or shortness of breath